Graneledone verrucosa (Verrill 1881), the type species of the genus Graneledone, is redescribed based on historical material and previously unreported specimens that have resulted from an increase in deep-sea fishing in the North East Atlantic. Graneledone verrucosa var. media (Joubin 1918) was found to be invalid and is herein synonymized with G. verrucosa. Graneledone verrucosa is shown to inhabit deep water throughout the North Atlantic; its distribution extends from 20degrees to 65degrees N and from 9degrees to 75degrees W. A revised diagnosis is given for the genus Graneledone Joubin, 1918.
View post tag: BAe Systems View post tag: US Navy Authorities US Navy orders more APKWSTM guidance kits Share this article Back to overview,Home naval-today US Navy orders more APKWSTM guidance kits The US Navy has contracted BAE Systems a $59.5 million contract to deliver additional APKWSTM guidance kits which transform unguided 2.75-inch (70-millimeter) rockets into laser-guided precision munitions.The new award, which follows a recent contract for $180.5 million, is part of a 2016 indefinite delivery / indefinite quantity contract for more than $600 million. With the new award, BAE Systems said it has further reduced the per-unit cost for APKWS laser-guided rockets, reinforcing its commitment to deliver customer value.“APKWS guidance kits are easy to use, cost-effective, and precise, and they seamlessly integrate with existing munitions and platforms,” said Rachel Guill, director of Precision Guidance Solutions at BAE Systems. “Our customers are demanding APKWS because of their extreme precision and mission effectiveness.”The APKWS laser-guidance kits enable warfighters to transform standard 2.75-inch rockets into precision munitions. The rockets enable critical airborne platforms — including A-10 Thunderbolt II, AH-64 Apache, AH-1W/Z Super Cobra/Viper, AV-8B Harrier, F-16 Fighting Falcon, UH-1Y Venom, and other fixed- and rotary-wing platforms — to deliver efficient weapons to soft and lightly armored targets in confined areas while minimizing collateral damage.APKWS rockets are the only guided 2.75-inch rockets qualified by the US Department of Defense and are used by the US Navy, US Marine Corps, US Army, and US Air Force. View post tag: APKWS October 12, 2017
Researchers at Oxford University are beginning the first human trial of a personalised cancer treatment this week. The new drug, called CXD101, will be investigated alongside a new test which could predict which patients could be successfully treated by this class of drug.One of the major challenges in drug development is that each patient responds differently to treatment. The presence of a test which could determine whether a patient could be successfully treated by the drug would save time for patients with quickly-developing cancers, avoid the cost of unnecessary treatments and prevent damaging side effects.Lead researcher Nick La Thangue, Professor of Cancer Biology at the University of Oxford, said, “This is really the shape of things to come, and avoids the problem of testing drugs on patients who have little chance of benefiting from the treatment.”Professor Mark Middleton, the clinical lead for the trial and Professor of Experimental Cancer Medicine at Oxford University, said, “As we grapple with the affordability of new drugs we are always looking for ways to define who benefits from new treatments. If we can develop a test to say who should have a new drug we save the NHS money, patients from trying ineffective treatment and spare them side effects unless there’s a good chance of benefitting from treatment. For CXD101 there’s a long way to go to reach this goal, but by evaluating the biomarker from the start we stand the best chance of making it clinically useful.” The clinical trial will investigate CXD101, a next-generation histone deacetylase (HDAC) inhibitor. This blocks HDAC enzymes, which are important in the regulation of gene expression. Blocking these enzymes can stop cancer cells from multiplying, and may even kill cancer cells entirely. The test for the efficacy of the drug involves measuring the levels of a protein biomarker, HR23B. A high level of protein has been shown to make tumours more vulnerable to CXD101. The trial will involve 30-40 cancer patients. The first group will be given increasing doses of the drug to determine the most effective dose. The second group will be tested for the biomarker, and those with high levels will be treated with the best dose of the drug. This has significant implications for the future of cancer treatment, and can be effective on a wide spectrum of cancers for late-stage cancer patients. Professor La Thangue said, “Any cancer could be high in HR23B, from breast cancers to blood cancers, so we are screening a broad range of patients to identify anyone who might benefit.”Personalised medicine has been growing in popularity over the past decade to increase the efficiency of treatment. Samuel Kim, a first year medic at Oxford University, said: “Personalised medicine has been the next ‘big thing’ in medicine for a while now, and it is good to see novel treatments being trialled here at Oxford. However, I do worry that it will follow much the same story as gene therapy; something that promises so much, but has delivered so little.”The drug and associated test are still in Stage I of clinical trials, and it will be a minimum of 10 years before it is implemented as a treatment for cancer.Marco Narajos, online editor of Bang Science and a first year medic, commented, “Whilst the trial for CXD101 and the biomarker is exciting, we’re definitely not out of the woods yet. Certainly, we don’t know yet if it works, how much it will cost the NHS, and whether it will cause short term or long term side effects, and call me a cynic, but certainly it won’t be a panacea for cancer. The drug is meant for late-stage cancer patients, and potentially it will be useful to extend the lives of these patients, even if for a few months. We can still be hopeful, and I am excited to see the results of the trial.”
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A funeral mass was celebrated May 24 at Immaculate Conception Church, Secaucus, for James R. Miller, 62. He passed away suddenly and peacefully on May 20 at his residence in Secaucus. Born and raised in Union City, Mr. Miller lived in Secaucus for the last 37 years. He was the Owner/Insurance Agent of the Longo Agency in Bayonne for 40 years. James is survived by his wife Linda of 40 years; two daughters, Nicole Miller of Secaucus, Tara Taveras and her husband Jose of Rutherford; three sons, James and his wife Lauren of Secaucus, Vincent and his wife Stephanie of Savannah, Ga., and Matthew of Secaucus; three grandchildren, Olivia, Weston, and Liana; his mother Eleanor Miller of Union City; brother John and his wife Cathy of Rochelle Park; a brother-in-law and sister-in-law Julianne and John Wasylyk of Rutherford; a brother-in-law Al Knoble and his fiance Michele Kahwajy; three nieces, Kaitlin Cuccinelli and her husband Ryan, Sharon Merlino and her husband Michael, and Susan DiBetta and her husband Peter.Services arranged by the Mack Memorial Home, Secaucus.
The School of Artisan Food is to focus more on its bakery training following an increased uptake and demand for its full-time diploma.The School, which was launched around three years ago and is based on the Welbeck Estate in North Nottinghamshire, is looking to focus on its Advanced Diploma in bakery as a one-year full-time course.Wayne Caddy, head of baking at The School of Artisan Food, told British Baker: “We are focusing more on the bakery year-long full-time Diploma now than the other skills, such as dairy and charcuterie, because of the whole interest around bakery. We are looking at ways of expanding the course such as increasing the work placement duration from six weeks to 10 instead.”He added that the School had seen great success from this year’s graduates for the full-time bakery diploma, with 40% running their own artisan bakery businesses and the remaining 60% working in the industry.”We are also going to be increasing the practical training on the course to four days a week instead of three, with a day of theory on elements such as business studies,” Caddy added. “Listening to the feedback of students has helped to shape the course for future potential bakers.”
Three people were arrested and two more were cited last weekend for minor consumption in off-campus areas heavily populated with Notre Dame students. The suspects were 19 and 20 years old. Three of the suspects gave Notre Dame campus addresses and two gave out-of-state addresses. These incidents came after police busted a party July 17 at 1017 E. Washington St. and took 43 people to jail for various alcohol charges. Those arrested included eight football players, one basketball player and nine hockey players. South Bend police responded to a call that a fight was occurring at the corner of Washington and Eddy streets and were dispatched at 1:41 a.m., according to the police report. “When the officers got there, they realized the fight had spilled over from 1017 E. Washington, so officers went to that house and they called for more units because there was a large party there,” the report stated. The officer exited his squad car and heard glass breaking from the rear of the house. A white male ran out from behind the building and continued to run when police ordered him to stop. Officers pursued him on foot, but were unable to catch him, the report said. People also jumped out of windows and from the roof of the residence, the report said. South Bend police called Indiana State Excise Police to assist them and were at the house for about an hour. It took three trips using the South Bend prisoner transport van and patrol vehicles to transport all of the suspects to St. Joseph County Jail, the report said. The suspects were kept in jail until their blood alcohol content levels returned to zero. For many of them, this took several hours and they were released the next morning. The decision to arrest was made by the South Bend police, said Lt. Tim Cleveland, excise police commander for the district in which the incident occurred. “The decision was made before our officers arrived,” he said. He said excise police make the decision to arrest based on circumstances. “If the individuals are too intoxicated to walk, then we’ll incarcerate,” Cleveland said. The blood alcohol levels for those arrested at the July 17 incident ranged from .02 to .16 percent. Twelve of the 43 individuals arrested had blood alcohol content levels of .05 percent or below. Several messages left for the South Bend police were not returned. Student body president Catherine Soler said student government is aware of these recent incidents and is “putting forth efforts to protect students, keep them safe and allow us to have fun while respecting the law and our neighbors.” Soler also said she is compiling reports of the incidents and encouraged anyone who has knowledge of an incident to contact student government. “We want people to come and tell us so we know what’s going on,” she said. “So when we talk to people we have testimonials.”
SYDNEY LUCASFun Home MAX VON ESSENAn American in Paris Tony night is almost here! As we count down the days until June 7, we’re getting more and more excited for the first-time Tony nominees who could be taking home a trophy for Best Actor or Actress this year. We asked you to rank the Tony newbies you’re rooting for on Culturalist. The results are in! Check out who you guys picked below. TONY YAZBECKOn the Town EMILY SKEGGSFun Home BETH MALONEFun Home BRADLEY COOPERThe Elephant Man ALEX SHARPThe Curious Incident of the Dog in the Night-Time LEANNE COPEAn American in Paris STEVEN BOYERHand to God ROBERT FAIRCHILDAn American in Paris View Comments
With rain being sparse in some areas of Georgia this summer, irrigation is a necessary expense all farmers have to consider. Whether it’s with the checkbook method, soil moisture sensors or software programs, cotton farmers have a plethora of options to choose from, says a University of Georgia Extension expert.Guy Collins, UGA Extension’s cotton agromomist, says during the three-week squaring period cotton crops need one inch of water per week depending on soil type and environmental conditions. The crop also needs this much water for the first week of bloom. A cotton crop’s water needs increase to one and a half inch during second week of bloom and top off at two inches for the third and fourth bloom weeks. For the fifth and sixth weeks of bloom, the crop’s water needs drop back to one and a half inches. That total drops further to one inch each week for the rest of the season until bolls begin to open in which irrigation ceases.For example, if a farmer’s cotton receives eight tenths of an inch of rain during the first part of the week of squaring, the crop only needs two tenths of an inch of irrigation later that week to reach the one-inch of water the crop needs for the week.Keeping up with the amount of water a cotton crop needs can be a confusing task and farmers also have to decide which irrigation method works best for their needs. “There’s not one method that’s superior to others. It just depends on the grower’s needs and what they can do,” Collins said.The checkbook method is an approach that’s suitable for growers that aren’t using sensors or any other way to calculate irrigation. It follows the growth curve of the plant. As cotton bolls develop and mature, the plant’s water requirements change. It’s important to consider how the amount of water needed by the plant changes throughout the season, regardless of the irrigation strategy used, Collins said.Unlike the checkbook method, sensor-based irrigation systems can more accurately account for other variables when determining the appropriate time to irrigate. Sensors measure the soil moisture and accurately determine how much moisture the cotton plants are receiving from the soil at a given point in time. According to Collins, a sensor can help the farmer account for differences in soil texture and rainfall and determine when to turn irrigation on and off. Without a sensor, the farmer’s just guessing, he said. Soil moisture sensors also help growers save money. Normally a 5-10 day dry period would be detrimental to a cotton crop. But that wasn’t the case during last year’s extremely wet summer. Without sensors, a farmer may have applied irrigation unnecessarily. Collins said sensors in the soil would have reported how much moisture still remained. Unlike other years, last year’s cotton crop would not have been harmed by going without water for 10 days because of frequent rains and surplus soil moisture. The 2014 season may be very different, as Georgia suffers through prolonged hot and dry spell in many areas.The downside to sensor-based irrigation, though, is the added expense and time they require. Collins said.An irrigation practice becoming more and more popular is subsurface drip irrigation — a way to water cotton beneath the soil. Collins said subsurface drip irrigation is ideal for smaller, odd-shaped fields not suitable for pivot irrigation. If a well is located nearby, subsurface drip irrigation may be an option. “All of a sudden, a field that would otherwise be a dry land field can now be irrigated, just through a different system,” Collins said.The benefit of this system is that it more accurately adjusts for rainfall. Because a farmer only irrigates a small portion at a time, the potential for water loss could be much less if it rains after an irrigation. “For example, in the pivot system, a farmer may apply an inch of water over a one or two-day period. But if a thunderstorm pops up later in the week and brings five-tenths of an inch of rain, there’s an excess of five-tenths of an inch of water. And, there’s five-tenths of an inch of irrigation that could have been saved,” Collins said.With the subsurface drip system, a farmer applies a couple of tenths of an inch of water per day. Since so little water is being distributed at one time, the farmer is less likely to lose valuable water if it rains later in the week.On the downside, drip systems require much higher maintenance than the pivot system, Collins said. This is why only a small percentage of farmers use the method, he said.In his UGA Extension work across the state, Collins meets growers that only irrigate when their cotton is wilting. He strongly advises against this. “Chances are, however, the farmer has already lost yields if the cotton is left without water for too long,” he said. For more information on cotton production in Georgia, see ugacotton.com.
The owner of the Entergy Vermont Yankee nuclear plant in Vernon and four other such plants has met with New York regulators to make a more attractive financial offer in its effort to spin off those reactors into a new company called Enexus. The new proposal, which the company said would reduce the debt of the new company by $1 billion, while increasing capitalization by $350 million, would likely require further federal and Vermont regulatory approval. The other plants are Pilgrim (Plymouth, MA), Indian Point 1&2 (New York), FitzPatrick (New York), and Palisades (Michigan).In a press release issued yesterday, Entergy Corporation (NYSE: ETR) and subsidiaries (Entergy Nuclear FitzPatrick, LLC, Entergy Nuclear Indian Point 2, LLC, Entergy Nuclear Indian Point 3, LLC, NewCo (Enexus Energy Corporation) and Entergy Nuclear Operations, Inc. (collectively, Entergy )) filed a motion Monday with the New York Public Service Commission (NYPSC) in connection with the company s proposed spin-off, announced in November 2007, of its non-utility nuclear business to be named Enexus Energy Corporation. The motion requests procedures and a schedule to enable the report of the Presiding Administrative Law Judges (ALJs) to be issued in time for the NYPSC to issue a final order no later than its regularly scheduled meeting in November so that the proposed reorganization can be completed by the end of this year, with closing to take place on a month end. The details of the proposed procedures and schedule, including enhancements to the proposed reorganization, are included in this release.New York ProcessIn January 2008, Entergy filed a petition requesting either a declaratory ruling that the NYPSC need not review its proposed spin-off or, in the alternative, approval of the reorganization and its associated financing. In May 2008, the NYPSC issued an order finding that because the reorganization involved nuclear facilities that play an important role in supporting reliable electric service in New York, there needed to be a limited review of its potential to harm captive New York utility ratepayers. The NYPSC emphasized that the public interest inquiry was tightly bounded , allowed 60 days for discovery, and assigned ALJs to establish further procedures. After a series of filings and rulings by the ALJs, in October 2008 the judges notified all active parties that an adequate record had been established and no further formal proceedings were warranted.In December 2008, based on comments and reply comments presented in the above process suggesting that a settlement might be reached, a Notice of Impending Settlement Negotiation was then filed and settlement discussions began with the trial staff of the NYPSC and the other parties. Settlement discussions, viewed by the company as productive, continued throughout the first half of 2009 until recently terminated. The primary focus of comments filed by the trial staff concerned the relative credit ratings of Entergy and Enexus for long-term unsecured bonds and the possibility thatEnexus lower rating might adversely affect its financial capability to ensure the reliable operation ofthe New York nuclear plants.During the course of the settlement discussions, Entergy endeavored to address and resolve those concerns. Despite the termination of settlement discussions, Entergy has developed further enhancements to the reorganization proposal that it believes resolve any concerns. Accordingly, Entergy is proposing to file an amended petition reflecting these enhancements for the NYPSC s consideration.Entergy believes that with these enhancements and Enexus financial strengths described in the original petition, the reorganization proposal should fully satisfy the concerns raised by the NYPSC about the adequacy of Enexus financial resources to operate the New York facilities as reliably as Entergy. The amended petition will also include Entergy s analysis showing how there will be adequate funding for both radiological and non-radiological decommissioning of the New York plant sites. The following table briefly outlines a few of the most salient aspects of the enhancements that will be described in more detail in the amended petition:Procedures and Schedule Proposed by EntergyEntergy has proposed the following procedures and schedule in order to permit the ALJs toissue a report in time for the NYPSC to issue a final order no later than its regularly scheduledmeeting in November so that the proposed reorganization can be completed by the end of this year: After settlement discussions ended, Entergy met with trial staff and other parties to discusshow the case should proceed going forward. Some of the parties took the position that there shouldbe a full hearing process, including the filing of testimony, preceded by up to six months ofadditional discovery. They also provided lists of issues that they want to be included in testimonyand a hearing. The issues raised by trial staff and other parties could delay resolution of this case bya year or more by interjecting issues far outside the scope to which the NYPSC and the ALJs haveprescribed for the case. In its petition, Entergy requests that the ALJs continue to enforce the scopethat the NYPSC imposed in its May 23, 2008 Order and preclude trial staff and other parties fromlitigating these broader issues.Benefits of the TransactionEntergy believes that the spin-off of its non-utility nuclear business is in the best interests ofits stakeholders, as well as the customers of the load serving entities in the regions in which itsnuclear facilities sell power. Accordingly, Entergy remains vigilant in seeking regulatory approval ofthe spin-off transaction.Entergy recognizes that the financial flexibility and strength of Enexus is of paramount importance. Ensuring the financial strength and flexibility of Enexus has been a critical area of focus for Entergy as it has prepared for Enexus to operate as a separate, independent company. Entergy believes its initially proposed terms for the spin-off afforded Enexus financial flexibility and strength that were more than adequate to meet the legal standard established for the regulatory approval of the reorganization. Nonetheless, in an effort to remove any possible basis for concern, further enhancements are being provided. Given these enhancements to the already robust financial attributes of Enexus, Entergy strongly believes that the separation of Enexus from Entergy will be good for New York and for the other states in which its facilities are located. Further, for purposes of reliably operating the New York facilities, Enexus will be positioned to be at least the financial equivalent of Entergy given Enexus significant financial resources and its singular focus on the merchant generation business.Entergy Corporation is an integrated energy company engaged primarily in electric power production and retail distribution operations. Entergy owns and operates power plants with approximately 30,000 megawatts of electric generating capacity, and it is the second-largest nuclear generator in the United States. Entergy delivers electricity to 2.7 million utility customers in Arkansas, Louisiana, Mississippi and Texas. Entergy has annual revenues of more than $13 billion and approximately 14,700 employees.Source: Entergy. New Orleans, La. July 14, 2009.